反应详情

温度

10 °C

To a solution of 9-formyl-7, 12-dioxaspiro[5,6]dodecane of formula IV (5 g) in methanol (15 ml) was added in small portions NaBH4 (0.5 g) while stirring the solution and maintaining the temperature at 10° C. After complete addition, the reaction mixture was stirred for 3 hr at 20° C. The product residue obtained after evaporation of methanol was treated with water (20 ml), extracted into ether and dried over K2CO3. Evaporation of ether gave 9-hydroxymethyl-7, 12-dioxaspiro[5,6]dodecane of formula V (5 g) of the drawings as colorless viscous liquid.

1. additionAfter complete addition
2. stirringthe reaction mixture was stirred for 3 hr at 20° C
3. customThe product residue obtained
4. customafter evaporation of methanol
5. additionwas treated with water (20 ml)
6. extractionextracted into ether
7. dry with materialdried over K2CO3
8. customEvaporation of ether