Triethylamine → HCID 86617446, compound

Participants

Reaction Steps

Into a clean flame dried 250 mL RBF under current of N2, was added 10.10 g (26 mmol) of 55. To this was added 100 mL of DCM and 5.5 mL (39 mmol) of Et3N. The reaction mixture was then cooled in an ice-water bath and 2.3 mL (29 mmol) of MsCl was added and stirred for 12 h at room temperature. The reaction was then diluted with 200 mL of DCM and washed successively with sat. aq. NaHCO3 (1×), H2O (2×), brine (1×), dried over MgSO4, filtered and the solvent evaporated under vacuum. The residue was then purified using combiflash (120 g silica column) with hexane/ethyl acetate as eluent to furnish 10.15 g (84%) of target product 56 as a white solid.

Provenance & Evidence