4-Amino-1-Boc-piperidine → HCID 58857804, compound

HRID 2353054Notes

Reaction equation

HRID 2353054 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH3:18])[CH:12]=3)=[CH:9][N:10]=2)[N:7]=1.[C:19]([O:23][C:24]([N:26]1[CH2:31][CH2:30][CH:29]([NH2:32])[CH2:28][CH2:27]1)=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([N:26]1[CH2:31][CH2:30][CH:29]([NH:32][C:2]2[CH:3]=[CH:4][C:5]3[N:6]([C:8]([C:11]4[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH3:18])[CH:12]=4)=[CH:9][N:10]=3)[N:7]=2)[CH2:28][CH2:27]1)=[O:25])([CH3:22])([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 58857782HCID 58857782, compound

Product 1

HCID 58857804HCID 58857804, compoundYield 59.8%

Procedure

292 mg of 4-[3-(2-methoxypyridin-4-yl)imidazo[1,2-b]pyridazin-6-ylamino]piperidine-1-carboxylic acid tert-butyl ester were prepared from 300 mg (1.15 mmol) of 6-chloro-3-(2-methoxypyridin-4-yl)imidazo[1,2-b]pyridazine (Example 1.14) and 230 mg (1.15 mmol) of 4-aminopiperidine-1-carboxylic acid tert-butyl ester (CAS No. 87120-72-7) by method A.

Sources & evidence

ORD record
ord-01c92dde07f1423fb9f04b130921afe8
Source dataset
uspto-grants-2010_07
Patent number
US07750000B2

Reaction notes

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