Acetone → 2-(2-Difluoromethylbenzimidazol-1-yl)-4-morpholino-6-(piperazin-1-yl)-1,3,5-triazine

Participants

Role	Name	HCID	Charge
Reactant	Acetone	HCID 180	—
Reactant	Piperazine	HCID 4837	—
Reactant	4-(4-chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine	HCID 22036872	—
Solvent	Water	HCID 962	—
Product	2-(2-Difluoromethylbenzimidazol-1-yl)-4-morpholino-6-(piperazin-1-yl)-1,3,5-triazine	HCID 11955695	93%

Reaction Steps

For example, a mixture of 6-chloro-2-(2-difluoromethylbenzimidazol-1-yl)-4-morpholino-1,3,5-triazine (3.66 g, 10 mmol), piperazine (3.45 g, 40 mmol), and acetone (50 ml) was stirred at room temperature for 16 hours. The reaction mixture was poured into water, and precipitated crystals were filtered, and washed with methanol to afford 2-(2-difluoromethylbenzimidazol-1-yl)-4-morpholino-6-(piperazin-1-yl)-1,3,5-triazine (3.87 g, 9.3 mmol) in a yield of 93% as colorless crystals.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07750001B2
Source dataset	uspto-grants-2010_07
ORD ID	ord-b459b475a89242349c4161669336249e
Source note	uspto-grants-2010_07