Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate | HCID 12522245 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 12765184 | HCID 12765184 | — |
Reaction Steps
To a stirred solution of Step 3 product (1 eq) and trimethyl orthoformate (4.00 eq) in MeOH (9.4 v/w) at 5° C. was bubbled HCl gas (approximately 5 eq) over 2 hours, maintaining a pot temperature of 5° C. Upon complete addition, the reaction mixture, under nitrogen, was heated to, and stirred at, reflux for 30 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07749997B2 |
|---|
| Source dataset | uspto-grants-2010_07 |
|---|
| ORD ID | ord-e03d5a6aebe04bcc8d27c969e6a696aa |
|---|
| Source note | uspto-grants-2010_07 |
|---|
