HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2353115Generated: October 31, 2026
Potassium Carbonate → HCID 57420344, compound
https://huagongshe.com/reaction/2353115
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 57420344 | HCID 57420344 | 98.5% |
Reaction Steps
Amine preparation: a mixture of BOC-piperazine (1.87 g), ethyl 2-bromoisobutyrate (5.90 g) and potassium carbonate (1.53 g) in MeCN (20 mL) was heated in a sealed tube at 80° C. for 3 days. The reaction mixture was cooled, diluted with chloroform, washed with brine, dried (MgSO4) and the solvent removed in vacuo. The residue was purified by flash column chromatography to yield 4-(1-ethoxycarbonyl-1-methyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (2.97 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07750002B2 |
|---|
| Source dataset | uspto-grants-2010_07 |
|---|
| ORD ID | ord-69ecee8d6e9d44f9891e0ba780d22d97 |
|---|
| Source note | uspto-grants-2010_07 |
|---|
