Isoamyl Nitrite → HCID 11525613, compound

HRID 2353119Notes

Reaction equation

HRID 2353119 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[N:11]=[C:12]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[C:13]3[S:18][C:17]([CH2:19][N:20]4[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]4)=[CH:16][C:14]=3[N:15]=2)[C:5]([CH3:9])=[C:6]([NH2:8])[CH:7]=1.[N:33](OCCC(C)C)=O>C(Cl)(Cl)Cl.C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]2[C:5]([CH:9]=[N:33][NH:8]2)=[C:4]([C:10]2[N:11]=[C:12]([N:27]3[CH2:28][CH2:29][O:30][CH2:31][CH2:32]3)[C:13]3[S:18][C:17]([CH2:19][N:20]4[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]4)=[CH:16][C:14]=3[N:15]=2)[CH:3]=1

Participants

5

Reactant 2

HCID 8053Isoamyl NitriteHCID 57493984HCID 57493984, compound

Product 1

HCID 11525613HCID 11525613, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6212ChloroformSolvent

Procedure

Prepared by treatment of 5-fluoro-2-methyl-3-[6-(4-methyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl]-phenylamine with isoamyl nitrite in chloroform and acetic acid.

Sources & evidence

ORD record
ord-da3ef5afe283452fb48b462c40450d66
Source dataset
uspto-grants-2010_07
Patent number
US07750002B2

Reaction notes

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