6-Methyl-2-pyridinecarboxaldehyde → HCID 57476922, compound

HRID 2353133Notes

Reaction equation

HRID 2353133 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=4)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[CH3:32][C:33]1N=[C:37]([CH2:39][N:40]2CCNCC2)[CH:36]=[CH:35][CH:34]=1.CC1[N:52]=C(C=O)C=CC=1>>[NH:52]1[C:32]2[C:37](=[C:36]([C:2]3[N:3]=[C:4]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)[C:5]4[S:10][C:9]([CH2:11][N:12]5[CH2:17][CH2:16][N:15]([CH2:18][C:19]6[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=6)[CH2:14][CH2:13]5)=[CH:8][C:6]=4[N:7]=3)[CH:35]=[CH:34][CH:33]=2)[CH:39]=[N:40]1

Participants

4

Reactant 3

HCID 707376-Methyl-2-pyridinecarboxaldehydeHCID 5116563HCID 5116563, compound2×HCID 57494015HCID 57494015, compound

Product 1

HCID 57476922HCID 57476922, compound

Procedure

Via 2-chloro-6-[4-(6-methyl-pyridin-2-ylmethyl)-piperazin-1-ylmethyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, prepared from 1-(6-methyl-pyridin-2-ylmethyl)-piperazine. The amine, 1-(6-methyl-pyridin-2-ylmethyl)-piperazine, was prepared using 6-methyl-2-pyridinecarboxaldehyde, analogous to 124.

Sources & evidence

ORD record
ord-1a7cd8e3f6f348ffa2811a3203bc6d6f
Source dataset
uspto-grants-2010_07
Patent number
US07750002B2

Reaction notes

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