(3S)-N-Methyl-3-piperidinecarboxamide → HCID 11598384, compound

HRID 2353158Notes

Reaction equation

HRID 2353158 reaction equation
[CH3:1][NH:2][C:3]([C@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][C:12]2[S:20][C:19]3[C:18]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:17][C:16](Cl)=[N:15][C:14]=3[CH:13]=2)[CH2:6]1)=[O:4].C[NH:29][C:30]([C@H:32]1[CH2:37][CH2:36][CH2:35][NH:34][CH2:33]1)=O.Cl.N1CCC[C@@H](C(O)=O)[CH2:40]1>>[CH3:1][NH:2][C:3]([C@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([CH2:11][C:12]2[S:20][C:19]3[C:18]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:17][C:16]([C:37]4[CH:36]=[CH:35][CH:40]=[C:30]5[C:32]=4[CH:33]=[N:34][NH:29]5)=[N:15][C:14]=3[CH:13]=2)[CH2:6]1)=[O:4]

Participants

4

Reactant 3

HCID 7175807(3S)-N-Methyl-3-piperidinecarboxamideHCID 24820499(3R)-Piperidine-3-carboxylic acid--hydrogen chloride (1/1)HCID 57494049HCID 57494049, compound

Product 1

HCID 11598384HCID 11598384, compound

Procedure

Via (S)-1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidine-3-carboxylic acid methylamide, prepared from (S)-piperidine-3-carboxylic acid methylamide. Amine preparation as for 154, utilizing (R)-(+)-nipecotic acid hydrochloride as the starting material.

Sources & evidence

ORD record
ord-6c0b852dd0d64cf6b641df8e3623b257
Source dataset
uspto-grants-2010_07
Patent number
US07750002B2

Reaction notes

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