Bromine → 3-Bromo-6-chloroimidazo(1,2-b)pyridazine

HRID 2353189Notes

Reaction equation

HRID 2353189 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:8]1[N:6]2[N:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-

Product 1

HCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazineYield 60%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 6-Chloro-imidazo[1,2-b]pyridazine (4) (500 mg, 0.0032 mol) was taken in glacial acetic acid (5 ml) and bromine (0.4 ml) was added slowly at room temperature. After 20 minutes, solid precipitated out and was filtered. The solid was washed with ether (3×15 ml) and dried under air to give 3-Bromo-6-chloro-imidazo[1,2-b]pyridazine (5) (400 mg, yield=60%).

Workup

  1. customsolid precipitated out and
  2. filtrationwas filtered
  3. washThe solid was washed with ether (3×15 ml)
  4. customdried under air

Sources & evidence

ORD record
ord-14d7584b6d664fa2895895f3b6c9289a
Source dataset
uspto-grants-2010_07
Patent number
US07750007B2

Reaction notes

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