HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2353195Generated: October 26, 2026
1-Methyl-4-piperidinemethanol → 7-Methyl-6-((1-methylpiperidin-4-yl)methoxy)-3-(3(trifluoromethoxy)phenyl) imidazo[1,2-b]pyridazine
https://huagongshe.com/reaction/2353195
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methyl-4-piperidinemethanol | HCID 271971 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | 6-Chloro-7-methyl-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine | HCID 59380263 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 7-Methyl-6-((1-methylpiperidin-4-yl)methoxy)-3-(3(trifluoromethoxy)phenyl) imidazo[1,2-b]pyridazine | HCID 25025851 | 118.4% |
Reaction Steps
To the toluene (5 mL) solvent was added Compound 11 (80 mg, 0.224 mmol), (1-methylpiperidine-4-yl)methanol 14 (47.3 mg, 0.366 mmol), ligand (14.41 mg, 0.037 mmol), NaOtBu (33.3 mg, 0.347 mmol) and Pd2(dba)3 (16.77, 0.018 mmol). The resulting reaction mixture was degassed for 10 min under argon and then was heated with microwave at 165° C. Concentration and preparative TLC (10% MeOH/DCM) afforded 111.5 mg (11.2%) of Compound 7-34.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07750007B2 |
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| Source dataset | uspto-grants-2010_07 |
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| ORD ID | ord-f70f3890a2d54224a9a6d1a8d2318563 |
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| Source note | uspto-grants-2010_07 |
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