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Hydrochloric Acid → 1-(4-Phenoxyphenyl)piperazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-(4-Phenoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 44818988 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 1-(4-Phenoxyphenyl)piperazine hydrochloride | HCID 44818804 | 99% |
反応手順
The title compound (2.8 g, 99%) was prepared from the compound from step 1 (3.0 g, 8.45 mmol) and 4N HCl in dioxane using the procedure described in step 2 of Example 4: MS (ESI) m/z 255 (M+H); 1H NMR (400 MHz, DMSO-d6) δ 3.22 (br, 4H), 3.34 (t, J=4.8 Hz, 4H), 6.91-6.98 (m, 4H), 7.03-7.09 (m, 3H), 7.34 (m, 2H), 9.23 (br, 2H). Anal. Calcd for C16H18N2O.2HCl.0.8H2O: C, 58.72; H, 6.16; N, 8.56. Found: C, 56.25; H, 6.37; N, 8.20.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07750012B2 |
| 出典データセット | uspto-grants-2010_07 |
| ORD ID | ord-e173d12c166546c89b1aa6757900efa7 |
| 出典メモ | uspto-grants-2010_07 |