Methyl 4-bromobutyrate → 4-[4-(4-Phenoxy-phenyl)-piperazin-1-yl]-butyric acid methyl ester

Participants

Reaction Steps

The title compound (106 mg, 32.6%) was prepared from the compound from step 2, Example 8 (165 mg, 0.9 mmol) and 4-bromo-butyric acid methyl ester (165 mg, 90 mmol) by the procedure described in step 3 of Example 4: MS (ESI) m/z 355 (M+H); 1H NMR (400 MHz, CDCl3) δ 1.84 (m, 2H), 2.36-2.44 (m, 4H), 2.60 (t, J=4.8 Hz, 4H), 3.14 (t, J=4.8 Hz, 4H), 3.68 (s, 3H), 6.89-7.04 (m, 7H), 7.26-7.29 (m, 1H).

Provenance & Evidence