Sodium Hydroxide → 2-[4-(4-Phenoxy-phenyl)-piperazin-1-yl]-acetic acid sodium salt

HRID 2353240Notes

Reaction equation

HRID 2353240 reaction equation
C[O:2][C:3](=[O:24])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:13][CH:12]=2)[CH2:7][CH2:6]1.[OH-].[Na+:26]>>[Na+:26].[O:17]([C:14]1[CH:13]=[CH:12][C:11]([N:8]2[CH2:9][CH2:10][N:5]([CH2:4][C:3]([O-:24])=[O:2])[CH2:6][CH2:7]2)=[CH:16][CH:15]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 574195622-[4-(4-Phenoxy-phenyl)-piperazin-1-yl]-acetic acid methyl ester

Product 1

HCID 589025282-[4-(4-Phenoxy-phenyl)-piperazin-1-yl]-acetic acid sodium saltYield 95.7%

Procedure

The title compound (96 mg, 95%) was prepared from the compound from step 1 (100 mg, 0.30 mmol) and 1N NaOH (0.3 mL, 0.3 mmol) by the procedure described in Example 2: MS (ESI) m/z 313 (M+H); 1H NMR (400 MHz, DMSO-d6) δ 2.57 (t, J=4.8 Hz, 4H), 2.67 (s, 2H), 3.07 (t, J=4.8 Hz, 4H), 6.89-6.96 (m, 6H), 7.04 (m, 1H), 7.32 (m, 2H).

Sources & evidence

ORD record
ord-6e11bdba23fb4e19ae2d2380d36e73ac
Source dataset
uspto-grants-2010_07
Patent number
US07750012B2

Reaction notes

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