Sodium Hydroxide → HCID 58902520, compound

HRID 2353244Notes

Reaction equation

HRID 2353244 reaction equation
C[O:2][C:3](=[O:25])[CH2:4][NH:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1.[OH-].[Na+:27]>>[Na+:27].[O:18]([C:15]1[CH:14]=[CH:13][C:12]([N:9]2[CH2:8][CH2:7][CH:6]([NH:5][CH2:4][C:3]([O-:25])=[O:2])[CH2:11][CH2:10]2)=[CH:17][CH:16]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68425801HCID 68425801, compound

Product 1

HCID 58902520HCID 58902520, compoundYield 94.3%

Procedure

The title compound (23 mg, 94%) was prepared from the compound from step 1 (24 mg, 0.07 mmol) and 1N NaOH (0.07 mL. 0.07 mmol) by the procedure described in Example 2: MS (ESI) m/z 327 (M+H); 1H NMR (400 MHz, DMSO-d6) δ 1.36 (m, 2H), 1.80 (m, 2H), 2.45-2.55 (m, 2H), 2.68 (dd, J=2.8, 12 Hz, 2H), 3.53 (m, 2H), 6.88-6.91 (m, 4H), 6.95 (m, 2H), 7.04 (m, 1H), 7.32 (m, 2H).

Sources & evidence

ORD record
ord-fa717994b5f44ee48126fd695e2d920d
Source dataset
uspto-grants-2010_07
Patent number
US07750012B2

Reaction notes

Loading…