Nitric Acid → HCID 16638331, compound

HRID 2353268Notes

Reaction equation

HRID 2353268 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]21[C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10]2.[N+:16]([O-])([OH:18])=[O:17]>>[N+:16]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[CH2:1][C:2]1([C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10]1)[CH2:3]2)([O-:18])=[O:17]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 2799991',3'-dihydrospiro[imidazolidine-4,2'-indene]-2,5-dione2×

Product 1

HCID 16638331HCID 16638331, compound

Procedure

A solution of (±)-spiro[imidazolidine-4,2′-indane]-2,5-dione (3.0 g, 14.8 mmol, described in Intermediate 5) in conc. nitric acid (33 mL) was stirred at ambient temperature for 1 h. The reaction was then poured onto crushed ice and the resultant solid was isolated by filtration. The crude material was recrystallized from ethanol to give the title compound as a yellow solid. MS: m/z=248 (M+1).

Workup

  1. additionThe reaction was then poured
  2. customonto crushed ice
  3. customthe resultant solid was isolated by filtration
  4. customThe crude material was recrystallized from ethanol

Sources & evidence

ORD record
ord-912588d19a894969960458de6fe61e6b
Source dataset
uspto-grants-2010_07
Patent number
US07750010B2

Reaction notes

Loading…