Hydrochloric Acid → HCID 11656082, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methyl [7-Chloro-5-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)imidazo[1,2-c]-pyrimidin-8-yl]acetate (0.100 g, 0.199 mmol) in dioxane (1.00 mL) was added 6N HCl aq. (0.5 mL) and heated to 100° C. for 22 hours. After cooling to room temperature, the volatiles was removed under reduced pressure to generate a precipitate which was suspended in water, collected by suction, rinsed with water and diethyl ether, and dried under high vacuum to give [7-chloro-5-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)imidazo[1,2-c]pyrimidin-8-yl]acetic acid as a white powder (0.020 g, 20%).

Provenance & Evidence