反应详情

To a solution of methyl [5-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)imidazo[1,2-c]-pyrimidin-8-yl]acetate (20 mg, 0.04 mmol) in methanol (1 mL) was added 1M NaOH aqueous solution (0.2 mL) at room temperature, and the mixture was stirred for 1 hour. After the removal of methanol under reduced pressure, water was added to the residue. The solution was washed with diethyl ether and neutralized by aqueous hydrochloric acid. The resulting precipitates were collected by filtration and dried under reduced pressure to give [5-(4-{[4-(trifluoromethyl)-benzoyl]amino}benzyl)imidazo[1,2-c]pyrimidin-8-yl]acetic acid (14.2 mg, 73%) as slightly brown solid.

1. customAfter the removal of methanol under reduced pressure, water
2. additionwas added to the residue
3. washThe solution was washed with diethyl ether
4. customThe resulting precipitates
5. filtrationwere collected by filtration
6. customdried under reduced pressure