1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 58830628, compound

Participants

Reaction Steps

A solution of Z/E (4-bromo-2,5-difluorophenyl)(4-pyridinyl)methanone oxime (Intermediate 5, 124 mg) and 1,8-diazabicyclo[5.4.0]undec-7-ene (40 mg) in tetrahydrofuran (1.5 ml) was heated at 150° C. in a microwave oven for 30 min. The solvent was removed under vacuum and the residue was triturated with a small quantity of methanol to give the title compound as a cream coloured solid (32 mg).

Provenance & Evidence