HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 45867410, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 6-Methoxynicotinic acid | HCID 592499 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Catalyst | HOAt | HCID 181649 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 45867410 | HCID 45867410 | 85.6% |
Reaction Steps
A mixture of 6-methoxynicotinic acid (0.784 g) in DMF (10 ml) was stirred with N,O-dimethylhydroxylamine hydrochloride (0.5 g), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.16 g) and 1-hydroxy-7-azabenzotriazole (50 mg). Triethylamine (1.67 ml) was added and the reaction mixture was stirred at room temperature for 18 h. The solvent was removed under vacuum and the residue was partitioned between ethyl acetate and water. The organic layer was separated using a hydrophobic filter tube and the solvent was evaporated to give the title compound as a colourless oil (0.86 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750026B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-c48847ddfd1e483386d7a942113bd4e6 |
| Source note | uspto-grants-2010_07 |