反应详情

温度

-78 °C

A mixture of 1,4-dibromo-2,5-difluorobenzene (1.36 g) in anhydrous THF (20 ml) and 1.6M n-BuLi in hexane (3.43 ml) was stirred at −78° C. under nitrogen for 20 min. The reaction mixture was added to 6-chloro-N-methyl-N-(methyloxy)-3-pyridinecarboxamide (0.921 g) in THF (20 ml) and stirred at −78° C. The mixture was then stirred at −70° C. for 30 min allowed to warm to room temperature then cooled again to −70° C. and treated with 10% aqueous ammonium chloride. The reaction mixture was warmed to room temperature and partitioned between ethyl acetate and 10% aqueous ammonium chloride. The organic layer was separated using a hydrophobic filter tube and the solvent was removed under vacuum. The residue was purified using a silica SPE cartridge eluting with petroleum ether/ethyl acetate (9:1 to 1:3) to give impure title compound (0.548 g).

1. stirringstirred at −78° C
2. stirringThe mixture was then stirred at −70° C. for 30 min
3. temperatureto warm to room temperature
4. temperaturethen cooled again to −70° C.
5. temperatureThe reaction mixture was warmed to room temperature
6. custompartitioned between ethyl acetate and 10% aqueous ammonium chloride
7. customThe organic layer was separated
8. customthe solvent was removed under vacuum
9. customThe residue was purified
10. washeluting with petroleum ether/ethyl acetate (9:1 to 1:3)