Sodium Bicarbonate → HCID 11188919, compound

Participants

Reaction Steps

The procedure for Example 1 was followed using 6-bromo-5-fluoro-3-(4-pyridinyl)-1,2-benzisoxazole (Intermediate 6, 25 mg), {5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid (24 mg), tetrakis(triphenylphosphine)palladium(0) (1 mg) and saturated aqueous sodium hydrogen carbonate (0.25 ml) in isopropanol (1 ml). Elution of the SPE cartridge (silica, 1 g) with cyclohexane/ethyl acetate (100:0 to 66:33) gave the title compound as a white solid (21 mg).

Provenance & Evidence