Diethyl Ether → HCID 68451230, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-cyclopropyl-3-fluoro-5-[5-fluoro-3-(4-pyridinyl)-1,2-benzisoxazol-6-yl]-4-methylbenzamide (Example 3, 12 mg) in chloroform (1 ml) under nitrogen was treated with M-CPBA (10 mg) and the mixture was stirred at 60° C. for 40 min. Further m-CPBA (10 mg) was added and stirring was continued for 1 h. The solution was applied to an Isolute amino cartridge (1 g) which was eluted with chloroform/methanol (100:0 to 90:10) to give a glass. Trituration using a small quantity of ether gave the title compound as a white powder (9 mg).

Provenance & Evidence