Sodium Bicarbonate → HCID 58830629, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4,7-dibromo-5-fluoro-3-[6-(methyloxy)-3-pyridinyl]-1H-indazole and 6-bromo-5-fluoro-3-[6-(methyloxy)-3-pyridinyl]-1H-indazole (2:1) (Intermediate 9, 20 mg), N-ethyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (Intermediate 10, 32 mg), 1M aqueous sodium bicarbonate (1 ml) and tetrakis(triphenylphosphine)palladium (6 mg) in isopropanol was heated in a sealed vessel by microwave at 150° C. for 15 min. The reaction mixture was partitioned between chloroform and water and the organic layer was separated using a hydrophobic filter tube. The organic layer was concentrated under vacuum and the residue was purified by reverse phase preparative HPLC to give the title compound (3 mg).

Provenance & Evidence