HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → Carvedilol HBr
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Carvedilol | HCID 2585 | — |
| Solvent | Propanol water | HCID 22595341 | — |
| Product | Carvedilol HBr | HCID 9957094 | — |
Reaction Steps
Carvedilol free base is dissolved in n-propanol/water (95:5), and stoichiometric hydrobromic acid is added. The solution is cooled, and crystallization ensues. The product is filtered, washed with process solvent, and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750036B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-1d3672117b8346ed8ca3965e0cb789bb |
| Source note | uspto-grants-2010_07 |