HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → Carvedilol HBr
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Carvedilol | HCID 2585 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Isopropyl Acetate | HCID 7915 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Carvedilol HBr | HCID 9957094 | — |
Reaction Steps
Carvedilol free base is dissolved in a solvent (dichloromethane, isopropyl acetate, and acetonitrile have been used) and anhydrous forms HBr is added (HBr in acetic acid or gaseous HBr). The solution is cooled, and crystallization ensues. The product is filtered, washed with process solvent, and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750036B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-e047ccd8d80e413191be860f60b5c300 |
| Source note | uspto-grants-2010_07 |