Acetone → HCID 86602153, compound

HRID 2353407Notes

Reaction equation

HRID 2353407 reaction equation
CC(C)=O.[CH3:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][NH:16][CH2:17][CH:18]([OH:34])[CH2:19][O:20][C:21]1[CH:22]=[CH:23][CH:24]=[C:25]2[NH:33][C:32]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:26]=12.[C:35]([OH:42])(=[O:41])/[CH:36]=[CH:37]\[C:38]([OH:40])=[O:39]>O>[CH3:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][NH:16][CH2:17][CH:18]([OH:34])[CH2:19][O:20][C:21]1[CH:22]=[CH:23][CH:24]=[C:25]2[NH:33][C:32]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:26]=12.[C:35]([O-:42])(=[O:41])/[CH:36]=[CH:37]\[C:38]([O-:40])=[O:39]

Participants

5

Reactant 3

HCID 180Acetone2×HCID 2585CarvedilolHCID 444266Maleic Acid

Product 1

HCID 86602153HCID 86602153, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A suitable reactor is charged with acetone (56 mL). The acetone solution is sequentially charged with carvedilol (15.0 grams) and water (8 mL). Upon addition of the water, the slurry dissolves completely with heating. To the solution is added 1 M of aqueous Maleic acid (1 Equiv. 36.9 mL.) The reaction mixture is stirred at between 17° C. and 35° C. The solid precipitate is formed over 10 hours to 24 hours. Later, the mixture is filtered and the cake is washed with a mixture of acetone and water (10 to 1) at 3 volume or 45.0 mL. The cake is dried under vacuum to a constant weight. The final weight is 14.08 grams.

Workup

  1. dissolutionthe slurry dissolves completely
  2. temperaturewith heating
  3. customThe solid precipitate is formed over 10 hours to 24 hours
  4. filtrationLater, the mixture is filtered
  5. washthe cake is washed with a mixture of acetone and water (10 to 1) at 3 volume or 45.0 mL
  6. customThe cake is dried under vacuum to a constant weight

Sources & evidence

ORD record
ord-1bf98a1f54a74362b03a8faac3a29655
Source dataset
uspto-grants-2010_07
Patent number
US07750036B2

Reaction notes

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