Trifluoroacetic acid methylene chloride → Phenylmethyl N-(1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)carbamate

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Reaction Steps

To the product from Step B was added 4 mL of 1:1 dichloromethane/trifluoroacetic acid, and the solution was stirred for 60 min then concentrated in vacuo. The crude oil was purified by preparative thin layer chromatography using an Analtech® 1500 micron plate (10% methanol/ethyl acetate, 1% concentrated ammonium hydroxide) to give the title compound as a white solid. LC/MS 259.2 (M+1).

Provenance & Evidence