Thioacetamide → HCID 15231189, compound

Participants

Reaction Conditions

Reaction Steps

To 4-bromo-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-one (159 mg) (W.-J Kim, et al., Heterocycles, 1995, 41, 1389-1398) in 2 mL of N,N-dimethylformamide was added ethanethioamide (38 mg) and the reaction mixture heated to 50° C. for 2 h. The mixture was cooled to ambient temperature and diluted with a mixture of ethyl acetate/saturated aqueous sodium bicarbonate solution (1:1, 20 mL). The layers were separated and the aqueous phase extracted with ethyl acetate (3×10 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered, evaporated in vacuo The product was used without further purification. LC/MS 313.1 (M+1).

Provenance & Evidence