反应详情

A solution of tert-butyl 3-(acetylamino)-4-hydroxypyrrolidine-1-carboxylate obtained in Step A (680 mg) in dichloromethane (8 mL) was treated with 1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1H)-one (1.77 g) and stirred overnight at room temperature. The solution was then evaporated and purified on a Biotage Horizon® system (silica, gradient 50-90% ethyl acetate in hexane) to yield the title compound. LC-MS 243.2 (M+1).

1. customThe solution was then evaporated
2. custompurified on a Biotage Horizon® system (silica, gradient 50-90% ethyl acetate in hexane)