HCID 86635442, compound → 2-Methyl-5,6-dihydro-4H-pyrrolo[3,4-D]oxazole

HRID 2353444Notes

Reaction equation

HRID 2353444 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][C:5]=2[N:6]=1>FC(F)(F)C(O)=O.ClCCl>[CH3:1][C:2]1[O:3][C:4]2[CH2:9][NH:8][CH2:7][C:5]=2[N:6]=1

Participants

4

Reactant 1

HCID 86635442HCID 86635442, compound

Product 1

HCID 454802682-Methyl-5,6-dihydro-4H-pyrrolo[3,4-D]oxazole

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

tert-Butyl 2-methyl-4,6-dihydro-5H-pyrrolo[3,4-d][1,3]oxazole-5-carboxylate (110 mg) obtained in Step C was dissolved in a mixture of trifluoroacetic acid and dichloromethane (2 mL, 1:1) and evaporated under reduced pressure after one h. The residue was then purified on a Biotage Horizon® system (silica, 4% methanol, 0.4% saturated ammonium hydroxide, 95.6% dichloromethane) to yield the title compound. LC-MS 125.2 (M+1).

Workup

  1. customevaporated under reduced pressure after one h
  2. customThe residue was then purified on a Biotage Horizon® system (silica, 4% methanol, 0.4% saturated ammonium hydroxide, 95.6% dichloromethane)

Sources & evidence

ORD record
ord-a2c30e1083b9463392d789df6cbb3569
Source dataset
uspto-grants-2010_07
Patent number
US07750034B2

Reaction notes

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