Benzamide → HCID 68717214, compound

Participants

Reaction Steps

To a solution of benzamide (1.38 g) in N,N-dimethylformamide (40 mL) at 0° C., sodium hydride (1.37 g, 60%) was added. The mixture was stirred at ambient temperature for 10 min followed by addition of 3,4-bis(chloromethyl)furan (1.88 g). The resulting mixture was stirred for two days, diluted with ice-water (50 mL) and extracted with ethyl acetate (3×20 mL). The combine organic layers were dried over anhydrous sodium sulfate, filtered and evaporated and purified on a Biotage Horizon® system (silica, ethyl acetate/hexane 40/60) to yield the title compound.

Provenance & Evidence