HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-5-(2-hydroxyethyl)thiazole → 5-(2-Methylsulfonyloxyethyl)-4-methylthiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-5-(2-hydroxyethyl)thiazole | HCID 1136 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-(2-Methylsulfonyloxyethyl)-4-methylthiazole | HCID 10104926 | — |
Reaction Steps
The 4-methyl-5-thiazole ethanol (Aldrich, 0.18 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750039B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-8014c292a4d44dd887fd5a2b51f96409 |
| Source note | uspto-grants-2010_07 |