HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Tert-butyl 4-(2-(methylsulfonyloxy)ethyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate | HCID 735736 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Tert-butyl 4-(2-(methylsulfonyloxy)ethyl)piperazine-1-carboxylate | HCID 22989493 | — |
Reaction Steps
A solution of tert-butyl-4-(2-hydroxyethyl)-piperazine-1-carboxylate (Maybridge, 0.29 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750039B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-0db6fb10180941c1b4899cb00834f29e |
| Source note | uspto-grants-2010_07 |