N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide → ITX-5061 free base

HRID 2353541Notes

Reaction equation

HRID 2353541 reaction equation
C(C1C=C([NH:17][C:18](=[O:40])[C:19]([C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]([O:31][CH2:32][CH2:33][N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)=[CH:23][CH:22]=2)=[O:20])N(C2C=CC(C)=CC=2)N=1)(C)(C)C.COC(=O)C(C1C2C(=CC=CC=2)C(OCCN2CCOCC2)=CC=1)=O.N[C:67]1[C:68]([O:82][CH3:83])=[C:69]([NH:77][S:78]([CH3:81])(=[O:80])=[O:79])[CH:70]=[C:71]([C:73]([CH3:76])([CH3:75])[CH3:74])[CH:72]=1>>[C:73]([C:71]1[CH:70]=[C:69]([NH:77][S:78]([CH3:81])(=[O:80])=[O:79])[C:68]([O:82][CH3:83])=[C:67]([NH:17][C:18](=[O:40])[C:19]([C:21]2[C:30]3[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:24]([O:31][CH2:32][CH2:33][N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)=[CH:23][CH:22]=2)=[O:20])[CH:72]=1)([CH3:76])([CH3:74])[CH3:75]

Participants

4

Reactant 3

HCID 10214710N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamideHCID 11376142HCID 11376142, compoundHCID 59379802HCID 59379802, compound

Product 1

HCID 11786594ITX-5061 free base

Procedure

The title compound was prepared by the same method described for compound 13 starting from compound 12 and compound 14. Calculated mass=583. Observed mass=584.

Sources & evidence

ORD record
ord-5d9047d36abe46e8943067e9f9980475
Source dataset
uspto-grants-2010_07
Patent number
US07749999B2

Reaction notes

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