HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-(4-Nitropyridin-2-yl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-Nitropyridine | HCID 70734 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(4-Nitropyridin-2-yl)morpholine | HCID 57418546 | 56.5% |
Reaction Steps
To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07749999B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-2980c9148a43422cb224823d9fcf9fe8 |
| Source note | uspto-grants-2010_07 |