HCID 59379802, compound → HCID 59379814, compound

HRID 2353582Notes

Reaction equation

HRID 2353582 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]([C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([O:16][CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:8][CH:7]=1)=[O:5]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:25])[CH:4]([OH:5])[C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([O:16][CH2:17][CH2:18][N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)=[CH:8][CH:7]=1

Participants

4

Reactant 1

HCID 59379802HCID 59379802, compound

Product 1

HCID 59379814HCID 59379814, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

To a solution of 12 (1 g, 2.9 mmol) in MeOH (10 mL), Pd/C (10 wt %) was added and the mixture stirred at rt under H2 atmosphere. Upon completion of the reaction (monitored by LCMS), the mixture was filtered through celite and the filtrate evaporated to give a yellow oil which solidified upon standing. Calculated mass=345. Observed mass=345.

Workup

  1. customUpon completion of the reaction (monitored by LCMS)
  2. filtrationthe mixture was filtered through celite
  3. customthe filtrate evaporated
  4. customto give a yellow oil which

Sources & evidence

ORD record
ord-7e8ec42059234162bb086a33bd50ea70
Source dataset
uspto-grants-2010_07
Patent number
US07749999B2

Reaction notes

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