Ethanol → HCID 76550040, compound

HRID 2353583Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([NH:19][C:20](=[O:42])[C:21]([C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:26]([O:33][CH2:34][CH2:35][N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)=[CH:25][CH:24]=2)=O)[C:8]([O:17][CH3:18])=[C:9]([CH:16]=1)[C:10]([NH:12][CH:13]1[CH2:15][CH2:14]1)=[O:11])([CH3:4])([CH3:3])[CH3:2].[CH2:43]([O:45][C:46]([NH:48][NH2:49])=[O:47])[CH3:44].[CH3:50]CO>CC(O)=O>[CH2:43]([O:45][C:46]([NH:48][N:49]=[C:21]([C:20](=[O:42])[NH:19][C:7]1[CH:6]=[C:5]([C:1]([CH3:3])([CH3:4])[CH3:2])[CH:16]=[C:9]([C:10](=[O:11])[NH:12][CH:13]([CH2:14][CH3:50])[CH3:15])[C:8]=1[O:17][CH3:18])[C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([O:33][CH2:34][CH2:35][N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)=[CH:25][CH:24]=1)=[O:47])[CH3:44]

Participants

Conditions

Temperature: 120 °C

Procedure

Compound 30 (44 mg, 0.077 mmol) was dissolved in EtOH (1 mL) and hydrazinecarboxylic acid ethyl ester (24 mg, 0.231 mmol) and 1 drop of AcOH were added. The reaction mixture was stirred at 120° C. for 15 hrs, after which the crude mixture was purified by LC/MS. The isomers separated and the desired isomer was taken on into the next step. Calculated mass=660. Observed mass=660.

Workup

customafter which the crude mixture was purified by LC/MS
customThe isomers separated

Sources & evidence

ORD record: ord-126e8f0902e041d096c3b85376cfa66b
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07749999B2

Reaction notes

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