5-tert-Butyl-o-anisidine → 4-{4-[3-(5-Tert-butyl-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidine-2-carboxylic acid methyl ester

HRID 23536ノート

反応式

HRID 23536 の反応式
[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9]([O:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15]([NH2:22])=[CH:14][CH:13]=2)[CH:8]=[CH:7][N:6]=1)=[O:4].C(C1C=CC(OC)=C(C=1)N)(C)(C)C.[C:36]([C:40]1[CH:41]=[CH:42][C:43]([O:69][CH3:70])=[C:44]([NH:46][C:47](NC2C3C(=CC=CC=3)C(OC3C=CN=C(C#N)N=3)=CC=2)=[O:48])[CH:45]=1)([CH3:39])([CH3:38])[CH3:37]>>[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9]([O:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15]([NH:22][C:47]([NH:46][C:44]3[CH:45]=[C:40]([C:36]([CH3:37])([CH3:39])[CH3:38])[CH:41]=[CH:42][C:43]=3[O:69][CH3:70])=[O:48])=[CH:14][CH:13]=2)[CH:8]=[CH:7][N:6]=1)=[O:4]

参加物

4

反応物 3

HCID 41763185-tert-Butyl-o-anisidineHCID 99124171-(5-Tert-butyl-2-methoxy-phenyl)-3-[4-(2-cyano-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureaHCID 574187814-(4-Amino-naphthalen-1-yloxy)-pyrimidine-2-carboxylic acid methyl ester

生成物 1

HCID 102786524-{4-[3-(5-Tert-butyl-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidine-2-carboxylic acid methyl ester

実験手順

The title compound was prepared from the above amine and 5-tert-butyl-2-methoxyaniline by the procedure described for 1-(5-tert-butyl-2-methoxy-phenyl)-3-[4-(2-cyano-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea (Example 1).

出典と根拠

ORDレコード
ord-724dd17be6c24fe292b9ebef47216276
出典データセット
uspto-grants-2005_02
特許番号
US06852717B2

反応ノート

読み込み中…