Propane, 1-bromo-3-fluoro- → HCID 11502589, compound

HRID 2353610Notes

Reaction equation

HRID 2353610 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][C:4]=1[O:10][CH3:11].Br[CH2:13][CH2:14][CH2:15][F:16].[CH3:17][C:18]1([CH3:31])[C@@H:20]2[CH2:21][C:22]3[C:26]([C@H:19]12)=[C:25]([CH3:27])[S:24][C:23]=3[C:28](O)=[O:29]>>[F:16][CH2:15][CH2:14][CH2:13][O:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][NH:1][C:28]([C:23]2[S:24][C:25]([CH3:27])=[C:26]3[C:22]=2[CH2:21][C@H:20]2[C:18]([CH3:31])([CH3:17])[C@H:19]23)=[O:29])=[C:4]([O:10][CH3:11])[CH:5]=1

Participants

4

Reactant 3

HCID 67699Propane, 1-bromo-3-fluoro-HCID 534043344-(Aminomethyl)-3-methoxyphenolHCID 57892448(1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid

Product 1

HCID 11502589HCID 11502589, compound

Procedure

(1aS,5aR)-1,1,2-Trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid 4-(3-fluoro-propoxy)-2-methoxy-benzylamide is prepared starting from 4-aminomethyl-3-methoxy-phenol, 1-bromo-3-fluoro-propane and (1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid in analogy to the procedures given in Example 36. LC-MS: tR=1.10 min, [M+1]+=418.14.

Sources & evidence

ORD record
ord-0790553d9717478aa9fcf05377d3274c
Source dataset
uspto-grants-2010_07
Patent number
US07750040B2

Reaction notes

Loading…