1-Bromo-2-methylpropane → HCID 11640237, compound

HRID 2353613Notes

Reaction equation

HRID 2353613 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][C:4]=1[O:10][CH3:11].Br[CH2:13][CH:14]([CH3:16])[CH3:15].[CH3:17][C:18]1([CH3:31])[C@@H:20]2[CH2:21][C:22]3[C:26]([C@H:19]12)=[C:25]([CH3:27])[S:24][C:23]=3[C:28](O)=[O:29]>>[CH2:13]([O:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][NH:1][C:28]([C:23]2[S:24][C:25]([CH3:27])=[C:26]3[C:22]=2[CH2:21][C@H:20]2[C:18]([CH3:31])([CH3:17])[C@H:19]23)=[O:29])=[C:4]([O:10][CH3:11])[CH:5]=1)[CH:14]([CH3:16])[CH3:15]

Participants

4

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 534043344-(Aminomethyl)-3-methoxyphenolHCID 57892448(1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid

Product 1

HCID 11640237HCID 11640237, compound

Procedure

(1aS,5aR)-1,1,2-Trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid 4-isobutoxy-2-methoxy-benzylamide is prepared starting from 4-aminomethyl-3-methoxy-phenol, 1-bromo-2-methyl-propane and (1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid in analogy to the procedures given in Example 36. LC-MS: tR=1.16 min, [M+1]+=414.17.

Sources & evidence

ORD record
ord-8621df3376d14801ae4d6c0984df0040
Source dataset
uspto-grants-2010_07
Patent number
US07750040B2

Reaction notes

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