HCID 59380605, compound → HCID 59380604, compound

HRID 2353620Notes

Reaction equation

HRID 2353620 reaction equation
CON(C)[C:4]([C:6]1[S:13][C:12]([CH3:14])=[C:11]2[C:7]=1[CH2:8][C@H:9]1[C:15]([CH3:17])([CH3:16])[C@H:10]12)=[O:5].[CH2:19]([Mg]Cl)[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:21]1([CH2:20][CH2:19][C:4]([C:6]2[S:13][C:12]([CH3:14])=[C:11]3[C:7]=2[CH2:8][C@H:9]2[C:15]([CH3:17])([CH3:16])[C@H:10]23)=[O:5])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 59380605HCID 59380605, compoundHCID 178418865HCID 178418865, compound

Product 1

HCID 59380604HCID 59380604, compound

Procedure

3-Phenyl-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]-pentalen-4-yl)-propan-1-one is prepared by reacting (1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]penta-lene-4-carboxylic acid methoxy-methyl-amide with phenethyl magnesium chloride in analogy to Example 48; LC-MS: tR=1.15, [m+1]+=311.00.

Sources & evidence

ORD record
ord-124ee0f6f5f34bf3a1647fff51bfb587
Source dataset
uspto-grants-2010_07
Patent number
US07750040B2

Reaction notes

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