Phenyl isocyanate → 1-[2-Methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]phenyl]-3-phenyl-urea

Participants

Reaction Conditions

Reaction Steps

2-Methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline (130 mg, 0.34 mmol) was dissolved in 1,4-dioxane (4 mL). Phenylisocyanate (0.038 mL, 0.34 mmol) was added and the reaction heated at 75° C. for 3 hours. The reaction mixture was evaporated to dryness and the resultant residue triturated with ethyl acetate to give the desired compound as a cream solid (42 mg).

Provenance & Evidence