Water → HCID 24803339, compound

Participants

Reaction Steps

1-[4-[4-(Cyclohexylsulfanylmethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]-3-methyl-urea (0.35 mmol) was dissolved in 1,4-dioxane (5 mL) and water (1 mL). 3-chloroperbenzoic acid (75%) (121 mg) was added to the solution followed immediately by sodium permanganate (140 mg) and the reactions stirred at RT for 1 hour. Further 3-chloroperbenzoic acid (75%) (121 mg) and sodium permanganate (140 mg) were added and the reactions allowed to stir at RT for 1 hour. Further 3-chloroperbenzoic acid (75%) (121 mg) and sodium permanganate (140 mg) were added and the reactions allowed to stir at RT for another 1 hour then loaded onto a SCX-3 column. The column was washed with methanol and the desired material removed with 7N ammonia in methanol. The crude material was purified by prep-HPLC (basic) to give the desired material (74 mg) as a white solid.

Provenance & Evidence