phenyl (4-{4-[1-methyl-1-(methylsulfonyl)ethyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl}phenyl)carbamate → 3-Methyl-1-[4-[4-(2-methylsulfonylpropan-2-yl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]urea
Reaction equation
[CH3:1][C:2]([C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:11]=[C:10]([C:20]2[CH:25]=[CH:24][C:23]([NH:26][C:27](=O)[O:28]C3C=CC=CC=3)=[CH:22][CH:21]=2)[N:9]=1)([S:4]([CH3:7])(=[O:6])=[O:5])[CH3:3].CC([C:43]1C=C(N2CCOC[C@@H]2C)N=C(C2C=CC(NC(=O)OC3C=CC=CC=3)=CC=2)[N:44]=1)(S(C)(=O)=O)C>>[CH3:43][NH:44][C:27](=[O:28])[NH:26][C:23]1[CH:22]=[CH:21][C:20]([C:10]2[N:9]=[C:8]([C:2]([S:4]([CH3:7])(=[O:5])=[O:6])([CH3:3])[CH3:1])[CH:13]=[C:12]([N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[N:11]=2)=[CH:25][CH:24]=1Participants
3
Reactant 2
Product 1
Procedure
The following compounds were prepared in analogous fashion from either phenyl (4-{4-[1-methyl-1-(methylsulfonyl)ethyl]-6-morpholin-4-ylpyrimidin-2-yl}phenyl)carbamate or phenyl (4-{4-[1-methyl-1-(methylsulfonyl)ethyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl}phenyl)carbamate and the appropriate amine.
Sources & evidence
- ORD record
- ord-cce3d71362564342b57df7f1a0f8fa8e
- Source dataset
- uspto-grants-2010_07
- Patent number
- US07750003B2
Reaction notes
Loading…