HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(N-Boc-amino)piperidine → 1-[4-[(3S)-3-methylmorpholin-4-yl]-6-(2-methylsulfonylpropan-2-yl)pyrimidin-2-yl]piperidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Reactant | 1-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]piperidin-4-amine | HCID 59380076 | — |
| Reactant | 2-chloro-4-[(3S)-3-methylmorpholin-4-yl]-6-(2-methylsulfonylpropan-2-yl)pyrimidine | HCID 59380220 | — |
| Product | 1-[4-[(3S)-3-methylmorpholin-4-yl]-6-(2-methylsulfonylpropan-2-yl)pyrimidin-2-yl]piperidin-4-amine | HCID 57427723 | — |
Reaction Steps
1-[4-[(3S)-3-methylmorpholin-4-yl]-6-(2-methylsulfonylpropan-2-yl)pyrimidin-2-yl]piperidin-4-amine was prepared from (3S)-4-{2-Chloro-6-[1-methyl-1-(methylsulfonyl)ethyl]pyrimidin-4-yl}-3-methylmorpholine and tert-butyl N-(4-piperidyl)carbamate in an analogous two step procedure to 1-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]piperidin-4-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750003B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-5aa03beb5de54383a8dd988db6916aa4 |
| Source note | uspto-grants-2010_07 |