Water → HCID 59379885, compound

Participants

Reaction Steps

N-Methyl-2-[[2-[4-(methylcarbamoylamino)phenyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-4-yl]methylsulfanyl]acetamide (0.35 mmol) was dissolved in 1,4-Dioxane (5 mL) and water (1 mL). m-CPBA (75%) (121 mg) followed immediately by sodium permanganate (140 mg) were added to the solution and the reaction stirred at RT for 1 h. Further m-CPBA (75%) (121 mg) followed immediately by sodium permanganate (140 mg) were added to the solution and stirred at RT for 1 h. Again further m-CPBA (75%) (121 mg) followed immediately by sodium permanganate (140 mg) were added and the reaction stirred at RT for 1 h. The reaction was loaded onto a SCX-3 (10 g) column, which was washed with methanol and the product eluted with 7N ammonia in methanol. The material was further purified by prep-HPLC (basic) to give the desired material (30 mg) as a white solid.

Provenance & Evidence