Morpholine → HCID 59380159, compound

Participants

Reaction Steps

1-[4-[4-(Hydroxymethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]-3-phenyl-urea (90 mg) was dissolved in DCM (5 mL) and triethylamine (0.045 mL) and the solution cooled to 0° C. Methane sulfonyl chloride (0.026 mL) was added and the reaction stirred for 1 h at RT. Morpholine (0.2 mL) was added and the reaction was left at RT for 72 hours before being concentrated in vacuo and purified by prep-HPLC (basic) to give the desired compound (64 mg) as a white solid.

Provenance & Evidence