Sodium Methoxide → HCID 59379912, compound

Participants

Reaction Steps

1-[4-[4-[(3S)-3-Methylmorpholin-4-yl]-6-(methylsulfonyloxymethyl)pyrimidin-2-yl]phenyl]-3-phenyl-urea (90 mg) dissolved in a solution of DCM (5 mL) and triethylamine (0.045 mL). Sodium methoxide (33% in methanol) (0.073 mL) was added to the reaction and the mixture stirred at RT for 18 h before being quenched with water and partitioned. The organic phase was dried over magnesium sulphate and evaporated to give a gum which was purified by prep-HPLC (basic) to give the desired compound (32 mg) as a white solid.

Provenance & Evidence