Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminopyrimidine | HCID 7978 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 59380022 | HCID 59380022 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68710452 | HCID 68710452 | — |
Reaction Steps
Phenyl N-[4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]carbamate (110 mg) was dissolved in DMF (2 mL) and triethylamine (0.098 mL) added. 2-Aminopyrimidine (108 mg) was added and the reaction stirred at 40° C. for 2 hours. The crude mixture was purified by prep-HPLC (basic), however, only [4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]urea was isolated from the mixture (8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07750003B2 |
|---|
| Source dataset | uspto-grants-2010_07 |
|---|
| ORD ID | ord-b9fa43dd347a49a295fa26aa67a4ff2c |
|---|
| Source note | uspto-grants-2010_07 |
|---|
